Siddhartha Mukherjee’s The Emperor of All Maladies became an instant classic when it was published in 2010. A  magnificent, humane “biography” of cancer—from its first documented  appearances thousands of years ago through the epic 20th century to cure, control, and conquer it to a radical new understanding of its  essence—The Emperor of All Maladies is one of the most highly acclaimed books of its time.

In the years since Mukherjee dazzled readers with The Emperor of All Maladies, much has changed in the universe of cancer—in our understanding of its causes; in our attempts to prevent it; and in the revolutionary new  treatments. In four profound and revelatory new chapters—essentially a new book about cancer—he illuminates this disease with both a bird’s eye view of the landscape and an acute focus on the role of the cell. He also looks at imminent new studies—and to the future.